Oxygen Sensing in the Pulmonary Circulation
نویسندگان
چکیده
منابع مشابه
Oxygen Sensing in the Pulmonary Circulation
Since the original description of hypoxic pulmonary vasoconstriction (HPV) by Von Euler and Liljestrand in 1946, where they concluded, “breathing of pure oxygen lowered the pulmonary arterial pressure and oxygen-lack raised it,” the precise oxygen-sensing mechanism within the lungs has remained an enigma. Nevertheless, there seems to be some agreement to an overall mechanism for HPV: the primar...
متن کاملInvited Review HIGHLIGHTED TOPIC Pulmonary Circulation and Hypoxia Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing
Waypa, Gregory B., and Paul T. Schumacker. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J Appl Physiol 98: 404–414, 2005; doi:10.1152/japplphysiol.00722.2004.—Recently, the mitochondria have become the focus of attention as the site of O2 sensing underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have emerged to explain how mitochondria rea...
متن کاملIron, oxygen, and the pulmonary circulation
The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This review describes the time course of this behavior, which occurs in distinct phases, and then explores the importance for HPV of the hypoxia-inducible factor (HIF) pathway. Next, the HIF-hydroxylase enzymes that act as molecular ...
متن کاملHypoxic pulmonary vasoconstriction: redox events in oxygen sensing.
Recently, the mitochondria have become the focus of attention as the site of O(2) sensing underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have emerged to explain how mitochondria react to a decrease in Po(2). One model proposes that a drop in Po(2) decreases the rate of mitochondrial reactive oxygen species (ROS) generation, resulting in a decrease in oxidant ...
متن کاملModel for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing.
We tested whether mitochondria function as the O(2) sensor underlying hypoxic pulmonary vasoconstriction (HPV). In buffer-perfused rat lungs, rotenone, myxothiazol, and diphenyleneiodonium, which inhibit mitochondria in the proximal region of the electron transport chain (ETC), abolished HPV without attenuating the response to U46619. Cyanide and antimycin A inhibit electron transfer in the dis...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.311518